Journal
TRAFFIC
Volume 14, Issue 6, Pages 622-628Publisher
WILEY
DOI: 10.1111/tra.12051
Keywords
endoplasmic reticulum quality control; membrane proteins; plant-protein sorting; plant vacuole; storage vacuoles; tonoplast; vesicle traffic
Categories
Funding
- European Union Marie Curie Research Training Network Vacuolar Transport Equipment for Growth Regulation of Plants [MRTN-CT-2006-035833]
- Italian Ministry of Education, Universities and Research [PRIN2010CSJX4F]
- Swiss National Science Foundation [SNF 31003A_127340]
- Swiss National Science Foundation (SNF) [31003A_127340] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Tonoplast, the membrane delimiting plant vacuoles, regulates ion, water and nutrient movement between the cytosol and the vacuolar lumen through the activity of its membrane proteins. Correct traffic of proteins from the endoplasmic reticulum (ER) to the tonoplast requires (i) approval by the ER quality control, (ii) motifs for exit from the ER and (iii) motifs that promote sorting to the tonoplast. Recent evidence suggests that this traffic follows different pathways that are protein-specific and could also reflect vacuole specialization for lytic or storage function. The routes can be distinguished based on their sensitivity to drugs such as brefeldin A and C834 as well as using mutant plants that are defective in adaptor proteins of vesicle coats, or dominant-negative mutants of Rab GTPases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available