Journal
TRAFFIC
Volume 12, Issue 8, Pages 948-955Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0854.2011.01188.x
Keywords
Alzheimer's disease; Charcot-Marie-Tooth disease; development; endocytosis; endosome; hereditary spastic paraplegia; retrograde; retromer; secretion; sorting; trans-Golgi network
Categories
Funding
- US National Institutes of Health
- American Heart Association
- National Science Council of Taiwan
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Bidirectional traffic between the Golgi apparatus and the endosomal system sustains the functions of the trans-Golgi network (TGN) in secretion and organelle biogenesis. Export of cargo from the TGN via anterograde trafficking pathways depletes the organelle of sorting receptors, processing proteases, SNARE molecules, and other factors, and these are subsequently retrieved from endosomes via the retrograde pathway. Recent studies indicate that retrograde trafficking is vital to early metazoan development, nutrient homeostasis, and for processes that protect against Alzheimer's and other neurological diseases.
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