Journal
TRAFFIC
Volume 12, Issue 2, Pages 162-169Publisher
WILEY
DOI: 10.1111/j.1600-0854.2010.01137.x
Keywords
effector; intracellular; Listeria; Salmonella; type III secretion system
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Funding
- National Institute of Allergy and Infectious Diseases, National Institutes of Health
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A variety of bacterial intracellular pathogens target the host cell ubiquitin system during invasion, a process that involves transient but fundamental changes in the actin cytoskeleton and plasma membrane. These changes are induced by bacterial proteins, which can be surface associated, secreted or injected directly into the host cell. Here, the invasion strategies of two extensively studied intracellular bacteria, Salmonella enterica serovar Typhimurium and Listeria monocytogenes, are used to illustrate some of the diverse ways by which bacterial pathogens intersect the host cell ubiquitin pathway.
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