Journal
TRAFFIC
Volume 12, Issue 2, Pages 149-161Publisher
WILEY
DOI: 10.1111/j.1600-0854.2010.01126.x
Keywords
cell polarity; degradation; DSL ligands; endocytosis; membrane protein sorting; Mind bomb; Neuralized; Notch signaling; ubiquitin
Categories
Funding
- CNRS
- Region Bretagne [2168]
- Association pour la Recherche sur le Cancer [4905]
- Fondation pour la Recherche Medicale
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The Notch signaling pathway regulates numerous aspects of metazoan development and tissue renewal. Deregulation or loss of Notch signaling is associated with a wide range of human disorders from developmental syndromes to cancer. Notch receptors and their ligands are widely expressed throughout development, yet Notch activation is robustly controlled in a spatio-temporal manner. Within the past decades, genetic screens and biochemical approaches led to the identification of more than 10 E3 ubiquitin ligases and deubiquitinating enzymes implicated in the regulation of the Notch pathway. In this review, we highlight the recent studies in Notch signaling that reveal how ubiquitination of components of the Notch pathway, ranging from degradation to regulation of membrane trafficking, impacts on the developmental control of the signaling activities of both Notch receptors and their ligands.
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