Journal
TRAFFIC
Volume 10, Issue 9, Pages 1209-1220Publisher
WILEY
DOI: 10.1111/j.1600-0854.2009.00922.x
Keywords
adaptor; clathrin; endocytosis; network; signalling; transcription
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Funding
- EU/Marie Curie Cancer Cure Early Stage Research Training (CANCURE) Fellowship
- Cancer Research UK Programme
- University of Cambridge
- Cancer Research UK
- Hutchison Whampoa Limited
- National Institute for Health Research (NIHR)
- MRC [G0500966] Funding Source: UKRI
- Medical Research Council [G0500966] Funding Source: researchfish
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A subset of proteins predominantly associated with early endosomes or implicated in clathrin-mediated endocytosis can shuttle between the cytoplasm and the nucleus. Although the endocytic functions of these proteins have been extensively studied, much less effort has been expended in exploring their nuclear roles. Membrane trafficking proteins can affect signalling and proliferation and this can be achieved either at a nuclear or endocytic level. Furthermore, some proteins, such as Huntingtin interacting protein 1, are known as cancer biomarkers. This review will highlight the limits of our understanding of their nuclear functions and the relevance of this to signalling and oncogenesis.
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