Journal
TRAFFIC
Volume 9, Issue 9, Pages 1425-1436Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0854.2008.00771.x
Keywords
acetylcholine; endocytosis; exocytosis; GABA; glutamate; large dense core vesicle; monoamines; sorting signal; synapse; synaptic transmission; synaptic vesicle; transporter
Categories
Funding
- NIEHS NIH HHS [P01 ES016732, ES015747, P01 ES016732-010002, R01 ES015747, R01 ES015747-03S2] Funding Source: Medline
- NIGMS NIH HHS [GM07185] Funding Source: Medline
- NIMH NIH HHS [R01 MH076900-03, T32/MH019384, MH076900, R01 MH076900] Funding Source: Medline
- NINDS NIH HHS [R01 NS051453-01, R01 NS051453] Funding Source: Medline
Ask authors/readers for more resources
Vesicular neurotransmitter transporters are required for the storage of all classical and amino acid neurotransmitters in secretory vesicles. Transporter expression can influence neurotransmitter storage and release, and trafficking targets the transporters to different types of secretory vesicles. Vesicular transporters traffic to synaptic vesicles (SVs) as well as large dense core vesicles and are recycled to SVs at the nerve terminal. Some of the intrinsic signals for these trafficking events have been defined and include a dileucine motif present in multiple transporter subtypes, an acidic cluster in the neural isoform of the vesicular monoamine transporter (VMAT) 2 and a polyproline motif in the vesicular glutamate transporter (VGLUT) 1. The sorting of VMAT2 and the vesicular acetylcholine transporter to secretory vesicles is regulated by phosphorylation. In addition, VGLUT1 uses alternative endocytic pathways for recycling back to SVs following exocytosis. Regulation of these sorting events has the potential to influence synaptic transmission and behavior.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available