Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 58, Issue -, Pages 145-153Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2014.03.006
Keywords
Cancer diagnosis; Cancer research; Cancer therapy; Circulating tumor cell; Detection; Diagnostics; Droplet microfluidics; Drug screening; Single-molecule detection; Single-cell analysis
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Funding
- Department of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center
- Chao Family Comprehensive Cancer Center at UC Irvine
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Genetic and functional heterogeneity of tumor cells represents major obstacles to cancer research, detection and effective treatment. In order to develop new therapeutic approaches in an era of personalized medicine, it is important to understand the functional characteristics of DNA, RNA, and proteins at the single-molecule level in individual cancer cells. Droplet microfluidics has emerged as a new tool that offers advantages in analyzing single molecules and single cells for high-throughput analysis with exceptional sensitivity. In this review, we highlight some recent reports that employed droplet microfluidics for cancer research, diagnostics, and therapeutics, and offer a view on future applications. (C) 2014 Elsevier Ltd. All rights reserved.
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