Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 58, Issue -, Pages 90-98Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2014.02.011
Keywords
Bioconjugation; Bioimaging; Biosensing; Cellular targeting; Detection; Fluorescent metal nanocluster; Fluorescent probe; In vivo; Optical imaging; Synthesis
Categories
Funding
- National Basic Research Program of China [2011CB933502]
- National Natural Science Foundation of China [21305120, 21335004, 21121091]
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Fluorescent metal nanoclusters (NCs) are a class of emerging fluorescent materials. They have excellent photostability and biocompatibility with sub-nanometer size and are easy to synthesize. Taking advantage of these features, fluorescent metal NCs have been involved in exciting developments of analytical methods for fluorescent biosensing and bioimaging. In this review, we first summarize the approaches to synthesis and bioconjugation for fluorescent metal NCs (Ag, Au, Cu and Pt). We then highlight their applications as fluorescent probes for metal ions, small molecules, nucleic acids, and protein detection. We also summarize the use of metal NCs in cellular and in-vivo targeting and imaging. Finally, we envision the various prospects for research on fluorescent metal NCs in the future. (C) 2014 Elsevier Ltd. All rights reserved.
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