Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 58, Issue -, Pages 31-39Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2014.03.008
Keywords
Biosensor; Diagnosis; Global health; Lateral-flow test strip; Nanomaterial; Nanobiosensing; Paper-based biosensor; Paper microfluidics; Point-of-care assay; Test strip
Categories
Funding
- National Natural Science Foundation of China [21275062, 21175032]
- Program for New Century Excellent Talents in University [NCET-12-0871]
- CounterACT Program, Office of the Director, National Institutes of Health (NIH)
- National Institute of Neurological Disorders and Stroke (NINDS) [U01 NS058161-01]
- NIH grant from the National Institute of Environmental Health Sciences (NIEHS) [U54 ES16015]
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Nanomaterial-enhanced paper-based biosensors, including lateral-flow test-strip (LFTS), and paper microfluidic devices, provide powerful analytical platforms for the development of affordable, portable, low-cost technologies for point-of-care and in-field assays. By combining with different kinds of nanopartides (NPs), the nanomaterial-based LFTS and paper microfluidic devices are showing great potential in enhancing detection sensitivity and selectivity. In this review, we provide a general overview of paper-based biosensing techniques, in which various NPs are involved, especially applications in biomedical and environmental studies. The first part provides detailed examples in LFTSs, while the second part gives a brief overview of paper microfluidics. Nanomaterial-enhanced paper-based biosensors could be used in physicians' office laboratories, nursing homes, hospitals, and the home. They may also make a great impact in global health in diagnosing health conditions in developing countries. (C) 2014 Elsevier Ltd. All rights reserved.
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