Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 56, Issue -, Pages 74-89Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2013.12.012
Keywords
Chiral drug; Chiral pharmaceutical; Chiral selector; Chiral separation; Chiral stationary phase; Drugs of abuse; Enantioseparation; Green Analytical Chemistry; Pharmaceutical analysis; Supercritical fluid chromatography
Categories
Funding
- National Science Centre in Poland [DEC-2012/05/N/ST4/ 02001]
- InnoDoktorant - Scholarships
- European Union as a part of the European Social Fund
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The supercritical fluid is an excellent choice as the chromatographic mobile phase because it allows rapid separation with high efficiency and applications involving enantioresolution are common. Supercritical fluid chromatography (SFC) is increasingly used for analytical, semi-preparative and preparative purification of chiral compounds, including production of enantiomers that are mainly encountered during drug development. SFC can be used as an alternative to HPLC for many drug substances, so it is gaining popularity in the pharmaceutical industry. The main advantages of SFC in separating chiral pharmaceuticals are: high speed, short analysis time, limited environmental impact and high efficiency. The reduction in the use of organic solvents has cost, health, and safety benefits. Due to these advantages, SFC fulfills all the requirements of Green Analytical Chemistry approaches. In this article, we present application of SFC as a tool for chiral separation of pharmaceuticals and drugs of abuse. (C) 2014 Elsevier Ltd. All rights reserved.
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