Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 61, Issue -, Pages 215-222Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2014.05.005
Keywords
Capillary electrophoresis; CE-MS; Energy metabolism; Mass spectrometry; Metabolite identification; Metabolome analysis; Metabolomics; Sample pretreatment; Separation; Sheathless interface
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Funding
- Yamagata Prefectural Government
- City of Tsuruoka, Japan
- Grants-in-Aid for Scientific Research [22134007] Funding Source: KAKEN
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Capillary electrophoresis-mass spectrometry (CE-MS) has emerged as a powerful new tool for comprehensive analysis of charged compounds. In this review, we provide a general description of the application of CE-MS in metabolome analysis, including the separation modes of CE, various interfaces and the mass spectrometers used. We also discuss strategies for sample pretreatment, data processing and peak identification, which are important processes in metabolome analysis. In addition, we highlight a number of new techniques to improve metabolite extraction, peak resolution and sensitivity. Finally, we provide some general conclusions and future perspectives. (C) 2014 Elsevier B.V. All rights reserved.
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