Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 59, Issue -, Pages 121-132Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2014.03.013
Keywords
Derivatization; Environmental analysis; Food-safety evaluation; Liquid chromatography; Mass spectrometric imaging; Mass spectrometry; Metabolite; Peptide; Pharmaceutical analysis; Protein
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Funding
- National Basic Research Program of China (973 Program) [2012CB720601, 2013CB910702]
- National Natural Science Foundation of China [91217309, 91017013, 21205091, 21228501]
- Fundamental Research Funds for the Central Universities
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Liquid chromatography-mass spectrometry (LC-MS) is one of the most prominent analytical techniques, due to its inherent selectivity and sensitivity. In LC-MS, chemical derivatizations are frequently used to enhance the MS ionization efficiency and selectivity, to facilitate structure elucidation, and to improve the chromatographic separation. In this review, we present an overview of derivatization-based LC-MS analysis. We summarize the reaction mechanisms of representative derivatization reagents and the selection strategy to guide and to stimulate future studies. Furthermore, we emphasize applications of derivatization in peptide and protein analysis, metabolite analysis, environmental analysis, pharmaceutical analysis, food-safety evaluation and MS imaging. (C) 2014 Elsevier B.V. All rights reserved.
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