Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 53, Issue -, Pages 106-116Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2013.08.010
Keywords
Anabolic androgenic steroid (AAS); Analytical strategy; Doping analysis; Forbidden substance; Glucuronide; Mass spectrometry (MS); Metabolism; Sample preparation; Steroid; Sulfate
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Funding
- Instituto de Salud Carlos III FEDER [CP10/00576]
- WADA [09A20RV, 11A9RV, 11A22OP]
- Ministerio de Economia y Competitividad (Spanish Government) [DEP2009-11454, DEP2012-35612]
- Generalitat de Catalunya [2009GR00492]
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Anabolic androgenic steroids (AASs) are synthetic substances derived from testosterone, whose use in sports is prohibited. This review underlines the advantages and the drawbacks of different coupled mass spectrometry-based approaches to the identification of MS metabolites. We discuss diverse aspects of the applications in the doping-control field, including sample preparation and instrumental analysis, with special emphasis on the potential scope of each strategy. (C) 2013 Elsevier Ltd. All rights reserved.
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