Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 45, Issue -, Pages 154-168Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2012.11.012
Keywords
Ambient mass spectrometry; Biological system; Biosensor; In vivo; Lab-on-a-chip; Microanalysis; Microextraction; Microsampling; Simulation; Spectroscopy
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This article reviews recent developments in in-vivo sampling and sample preparation for analysis of biological systems. The trend towards microanalytical techniques is justified by the small amount of sample that is available from some biological systems and the need to minimize interference with the system that is being studied or analyzed. Different approaches to direct in-vivo sampling and sample preparation are described, including microsampling, ultrafiltration, microextraction, microdialysis, solid-phase microextraction, biosensors, ambient mass spectrometry, spectroscopy, and microfluidic devices. (C) 2013 Elsevier Ltd. All rights reserved.
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