Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 49, Issue -, Pages 89-99Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2013.06.005
Keywords
Database tool; Degradation; Drug; Drug degradation product; Enrichment; Isolation; Mass spectrometry (MS); Nuclear magnetic resonance (NMR); Prediction; Structure elucidation
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Drug degradation prediction, chemical-based experiments, isolation and structure-elucidation techniques are all tools used to develop drug candidates. Structure elucidation often requires isolation, degradation chemistry, mass spectrometry and nuclear magnetic resonance spectroscopy. This article gives an overview of these state-of-the-art technologies being utilized in industry and how they are integrated in a workflow to facilitate structure determination of drug degradation products. (C) 2013 Elsevier Ltd. All rights reserved.
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