Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 48, Issue -, Pages 132-143Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2013.04.006
Keywords
Automated workflow; Biopharmaceuticals; Biotherapeutics; Capillary electrophoresis (CE); Carbohydrate sequencing; Glycoanalysis; High-sensitivity detection; Immunogenic epitope; N-glycosylation; Purity assessment
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Funding
- MTA-PE Translational Glycomics Grant of the Hungarian Academy of Sciences [97101]
- Fulbright Research Scholar Grant [I-174444]
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In N-glycosylation analysis of biopharmaceuticals, analytical need depends on the phase of the manufacturing process. All important glycoanalysis steps are thoroughly discussed. Carbohydrate sequencing by exoglycosidase arrays is described in conjunction with capillary electrophoresis (CE) to identify linkage and positional isomers. A possible automated workflow for N-glycosylation based on CE is outlined. (c) 2013 Elsevier Ltd. All rights reserved.
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