Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 37, Issue -, Pages 101-111Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2012.03.008
Keywords
DNA detection; Electrochemical DNA biosensor; Enzyme-amplified electrochemical DNA assay; Hairpin DNA; Hybridization; Locked nucleic acid; Mediator; Nanomaterial; Nucleic-acid biosensor; Peptide nucleic acid
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Funding
- National High Technology and Development of China (863 Project) [2008AA02Z433, SS2012AA023704]
- National Natural Science Foundation of China [20805006, 20975021, 21175023, 81171668]
- Fujian Provincial University-Industry Cooperation Science & Technology Major Program [2010Y4003]
- Foundation of Fujian Key Laboratory of Hematology [2009J1004]
- Fujian Medical University [09ZD013]
- Natural Science Foundation of Fujian Province of China [2010J06011]
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Due to the rapid response, the high sensitivity, the good selectivity and the experimental convenience of the electrochemical DNA biosensor, its applications have attracted broad interest. This article reviews electrochemical DNA biosensors and different methods proposed for their construction to overcome their limitations in selectivity and sensitivity. We also discuss their performance and future prospects. (C) 2012 Elsevier Ltd. All rights reserved.
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