Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 39, Issue -, Pages 180-194Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2012.07.006
Keywords
Biochemical; Chiral stationary phase (CSP); Chromatography; Computational chemistry; Enantioseparation; High-performance liquid chromatography (HPLC); Preparation; Recognition; Rational design; Resolution
Categories
Funding
- National Basic Research Program of China [2009CB421603]
- National Natural Science Foundations of China [20837002, 21177112]
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Chromatography technology based on chiral stationary phases (CSPs) for enantioseparation is widely used for resolution and preparation of biochemicals (e.g., drugs, foods, fragrances and pollutants). In this review, we focus on the development of CSPs for high-performance liquid chromatography (HPLC), including the recognition mechanism, applications and limitations of classical CSPs, newly discovered types of CSP, and also the methods for the rational design of future CSPs on the basis of computational chemistry. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.
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