4.7 Article

Bioanalysis based on nanoporous materials

Journal

TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 39, Issue -, Pages 149-162

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2012.05.008

Keywords

Bioanalysis; Biorecognition; Biosensing; Electrocatalysis; Electrochemical biosensor; Mesoporous material; Nanoporous material; Pore; Proteomics analysis; Zeolite

Funding

  1. National Natural Science Foundation of China [21175069, 21121091]
  2. New Century Excellent Talents in University of the Chinese Ministry of Education [NCET-09-0159]
  3. Foundation of the Jiangsu Education Committee [11KJA150003]
  4. Research Fund for the Doctoral Program of Higher Education of China [20113207110005]
  5. Priority Academic Program Development of Jiangsu Higher Education Institutions

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Nanoporous materials possess nanometer-sized pore distribution and are widely used in biosensing. The unique properties of nanoporous materials include large surface area, good chemical, thermal and mechanical stability, very uniform pore distribution with tunable pore size, high adsorption capacity, and an ordered porous network for free diffusion of substrates and reaction products. Usage of nanoporous materials can significantly improve the analytical performance of biosensors in biomedical diagnosis and monitoring of food and environmental quality. This article reviews some major advances in bioanalysis based on nanoporous materials, including biosensing based on zeolite, mesoporous silica, mesoporous carbon, mesoporous metal and metal oxide. These nanoporous materials have shown promising applications in electrochemical biosensing, electrocatalysis, proteomics analysis and biorecognition. (c) 2012 Elsevier Ltd. All rights reserved.

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