Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 34, Issue -, Pages 1-21Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2011.10.013
Keywords
Comprehensive two-dimensional gas chromatography (GC x GC); Cryotrapping; Flow switching; Heart cut; High-resolution chromatography; Microfluidics; Multi-dimensional gas chromatography (MDGC); Multidimensional separation; Orthogonality; Volatile sample
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Funding
- School of Chemistry and Faculty of Science, Monash University
- Royal Thai Government
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Analytical multidimensional gas chromatography (MDGC) and the excellent separation efficiency it achieves serve advanced characterization of complex volatile and semi-volatile samples, which is unlikely to be accomplished by single-dimensional chromatography. Here, we provide a technical overview of recent method implementation in MDGC, for both the classical sense (i.e. conventional heart-cut MDGC), including recent approaches to MDGC, and the comprehensive two-dimensional gas chromatography (GC x GC) variant. We summarize selected applications in diverse fields that best typify the role of these methods. We also draw attention to concepts (e.g., orthogonality of separation mechanisms and recently introduced microfluidic technology), and briefly comment on compatibility of detection systems. As a guide to potential opportunities for continued innovation in multidimensional applications, we highlight the capabilities of GC platforms that either combine various GC x GC and MDGC arrangements or offer alternative operational modes for implementation of these methods. (C) 2012 Elsevier Ltd. All rights reserved.
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