Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 30, Issue 9, Pages 1462-1476Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2011.06.011
Keywords
In-vivo analysis; Nanomaterial safety; Non-invasive detection; On-site analysis; Raman imaging; Raman scattering; Structure information; Surface analysis; Surface-enhanced Raman scattering; Ultra-sensitivity
Categories
Funding
- National Science Fund for Distinguished Young Scholars [21025729]
- National Basic Research Program of China [2011CB936001]
- National Natural Science Foundation of China [20921063, 20977101]
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Raman-based technologies have proved to be excellent tools for on-site and in-vivo analysis, due to the non-invasive nature of their detection, their capability of providing structure information, their high tolerance to aqueous samples, the ultra-sensitivity of surface-enhanced Raman scattering (SERS) and resonance Raman scattering (RRS), the high spatial resolution of tip-enhanced Raman scattering (TERS), and the ultrashort spectra-acquisition time for coherent anti-Stokes Raman scattering (CARS) and stimulated Raman scattering (SRS). In this review, we highlight the recent success of Raman-based technologies in various applications, including: (1) on-site surface analysis and chemical-reaction monitoring; (2) on-site identification of cultural objects, archeological studies and planetary science; (3) in-vivo analysis of cells and microorganisms; (4) in-vivo diagnosis inside human and animal bodies; (5) in-vivo fast Raman imaging and mapping; (6) the study of SERS processes; and, (7) assessment of nanomaterial safety. (C) 2011 Elsevier Ltd. All rights reserved.
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