Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 30, Issue 1, Pages 153-164Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2010.08.007
Keywords
Lab-on-a-valve; Flow analysis; Bead-injection analysis; Capillary electrophoresis; Gas chromatography; Liquid chromatography; Mesofluidic; Micro affinity chromatography; Micro solid-phase extraction
Categories
Funding
- Spanish Ministry of Science and Innovation [CTM2010-17214]
- Fundacao para a Ciencia e Tecnologia [HP2008-0045, E-48/09]
Ask authors/readers for more resources
The lab-on-a-valve (LOV) integrated microdevice has recently attracted much attention as a functional mesofluidic platform for programmable, pressure-driven flow as compared to lab-on-a-chip counterparts. We review the current state of the art of LOV as a versatile front end to column-separation techniques, namely, liquid chromatography (LC), gas chromatography (GC) and capillary electrophoresis (CE) for automatic mesofluidic handling at the low-microliter level, in-line sample processing and introducing the appropriate form of the analyte into the instrument for separation or detection. The open architecture of the LOV monolith unit has been to date exploited to accommodate micro solid-phase extraction in a renewable fashion, the so-called bead-injection analysis, encompassing reversed-phase materials and molecularly imprinted polymers, and in-valve microscale affinity chromatography. A plethora of interfaces have been recently devised for reliable injection of minute, well-defined volumes of analyte-containing solutions into LC,GC or CE We illustrate these applications with representative examples in environmental and bioanalytical arenas. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available