Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 30, Issue 7, Pages 1139-1158Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2011.03.013
Keywords
Amphetamine; Amphetamine analogue; Chiral derivatization; Chirality; Chiral separation; Enantiomer; Gas chromatography; High-performance liquid chromatography; Liquid chromatography; Thin-layer chromatography
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This article reviews the most common, useful methods for the chiral determination of amphetamine (AM) and AM-derived designer drugs in different of matrix, including blood, hair, urine, medicaments or standard solutions, taking into consideration articles published in the past 15 years. We consider chromatographic methods (e.g., gas, liquid, high-performance liquid, and thin layer). We describe several types of chiral derivatization reagent, mobile-phase additive and chiral stationary phase commonly used in the chromatographic methods. Tables summarize basic information about conditions (e.g., type of column and mobile phase), detection mode and reference data for each procedure. (C) 2011 Elsevier Ltd. All rights reserved.
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