Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 29, Issue 10, Pages 1157-1171Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2010.07.010
Keywords
Ambient mass spectrometry; Cost-effective analysis; Coupling to mass spectrometry; Desorption-based technique; Elution-based technique; High-performance thin-layer chromatography; HPTLC-MS; Planar chromatography; Thin-layer chromatography
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Coupling of planar chromatography to mass spectrometry (MS) and especially ambient MS is a relatively new field of great interest. The direct sample access at ambient conditions and the feasibility to obtain mass spectra free of contamination within a minute or even within seconds greatly contributes to the progress of planar chromatography. Targeted recording of mass spectra on zones of interest is performed after evaluation of the chromatogram, thus providing high efficiency. Reported approaches for coupling are divided into elution-based and desorption-based techniques. Devices of both categories are commercially available. As a consequence of increasing importance, a rethink of the terminology of liquid chromatography with MS has to be considered. (C) 2010 Elsevier Ltd. All rights reserved.
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