Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 27, Issue 3, Pages 251-260Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2008.01.008
Keywords
global metabolite profiling; metabolomics; metabonomics; metabotyping; separation; spectroscopic analysis
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in order to perform metabonomic investigations, it is necessary to generate comprehensive global metabolite profiles from complex samples, such as biofluids and tissues/tissue extracts. Analytical technologies based on liquid chromatography coupled to mass spectrometry (LC-MS) are destined to become a major source of global metabolite profiling data. Here, we describe and compare the utility of various analytical strategies and techniques currently used for LC-MS (capillary, high-performance and ultra-performance). We describe current challenges in the application of LC-MS-based techniques for metabonomic analysis. (c) 2008 Elsevier Ltd. All rights reserved.
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