Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 27, Issue 11, Pages 973-990Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2008.09.009
Keywords
Degradation product; Food; Large-scale multi-residue method; Liquid chromatography; Mass spectrometry; Pesticide; Tandem mass spectrometry; Target analysis; Time-of-flight; Trace analysis
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Funding
- European Commission [2007/1, SANCO/2007/FOOD, SAFETY/025]
- Ministerio de Educacion y Ciencia [BQU-2006-15066]
- [FQM-01463]
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Pesticide testing in foodstuffs is a challenging application for mass spectrometry (MS), since it implies simultaneous trace analysis of hundreds of compounds belonging to a many classes, preferably undertaken in one fast run. The appearance and the use of new, more polar pesticides has prompted the use of liquid chromatography electrospray ionization MS (LC-ESI-MS) instead of gas chromatography. Currently, large-scale multi-residue methods (LSMRMs) (i.e. covering over 80 analytes) for pesticide analysis are developed using LC with tandem MS (LC-MS2) With triple quadrupole mass analyzers or LC with time-of-flight MS (LC-TOF-MS). The present article provides a review of the most significant MRMs for determining pesticide residues in foodstuffs. We discuss the main features of LC-MS2 and LC-TOF-MS instruments, including recently introduced advances in instrumentation. in addition, we describe the advantages and the pitfalls of these methods, together with examples of the application of LC-TOF-MS and LC-MS2 to large-scale screening, identification and quantitation of pesticides in foodstuffs. (C) 2008 Elsevier Ltd. All rights reserved.
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