Journal
TOXICON
Volume 70, Issue -, Pages 82-85Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2013.04.009
Keywords
Calcium channels; Macrophages; Conus californicus; Inflammation
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Funding
- National Council of Science and Technology of Mexico (CONACYT)
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This study presents the effects of two synthetic disulfide bond variants of cal16b, a 13-mer Ca2+ channel blocker conotoxin, on pro- and anti-inflammatory cytokine gene transcription in the murine macrophage-like cell line J774A.1 stimulated with LPS. The globular form (cal16b_1) acted as an anti-inflammatory agent; in contrast, the ribbon disulfide variant (cal16b_2) had a pro-inflammatory effect. Our results suggest that the pro- and anti-inflammatory effects are mediated by the three-dimensional structure. (C) 2013 Elsevier Ltd. All rights reserved.
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