Journal
TOXICON
Volume 72, Issue -, Pages 29-34Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.toxicon.2013.04.005
Keywords
Toxin; Neutralizing antibodies; Biodefense; Mouse
Categories
Funding
- National Institutes of Health [AI097688]
- Wadsworth Center's Biodefense and Emerging Infectious Diseases program [T32AI055429]
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SylH3 and 24B11 are murine monoclonal antibodies directed against different epitopes on ricin toxin's binding (RTB) subunit that have been shown to passively protect mice against ricin challenge. Here we report that Fab fragments of SylH3 and 24B11 neutralize ricin in a cell based assay, and in a mouse challenge model as effectively as their respective full length parental IgGs. These data demonstrate that immunity to ricin can occur independent of Fc-mediated clearance. (C) 2013 Elsevier Ltd. All rights reserved.
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