Journal
TOXICOLOGY MECHANISMS AND METHODS
Volume 23, Issue 6, Pages 449-458Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/15376516.2013.780275
Keywords
2,4-Diclorophenoxyacetic acid; lipid peroxidation; lipidic status; liver; oxidative stress; rat
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Funding
- Ministere de l'Enseignement Superieur, de la Recherche Scientifique et de la Technologie (Tunis, Tunisia) [UR03/ES-08]
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This study aims to investigate the effects of the 2,4-dichlorophenoxyacetic herbicide (2,4-D) on plasma lipids, lipoproteins concentrations, hepatic lipid peroxidation, fatty acid composition and antioxidant enzyme activities in rats. Animals were randomly divided into four groups of 10 each: control group and three 2,4-D-treated groups G1, G2 and G3 were administered 15, 75 and 150 mg/kg/BW/d 2,4-D by gavage for 28 d, respectively. Results showed that 2,4-D caused significant negative changes in the biochemical parameters investigated. The malondialdehyde level was significantly increased in 2,4-D-treated groups. Fatty acid composition of the liver was also significantly changed with 2,4-D exposure. Furthermore, the hepatic antioxidant enzyme activities were significantly affected. Finally, 2,4-D at the studied doses modifies lipidic status, disrupt lipid metabolism and induce hepatic oxidative stress. In conclusion, at higher doses, 2,4-D may play an important role in the development of vascular disease via metabolic disorder of lipoproteins, lipid peroxidation and oxidative stress.
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