Journal
TOXICOLOGY LETTERS
Volume 225, Issue 2, Pages 294-304Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2013.12.015
Keywords
Zinc oxide nanoparticles; Isoorientin; Apoptosis; Mitochondrial stress; PI3K/Akt; MAPKs
Categories
Funding
- National Natural Science Foundation of China [31271810]
- Young Scientists Fund of the National Natural Science Foundation of China [31000757]
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Metal nanomaterial could effectively decrease tumour resistance to anti-cancer drugs. In this paper, we have explored the synergistic effect and mechanisms of zinc oxide nanoparticles (ZnO Nps) and isoorientin (ISO) on cytotoxicity in human hepatoma (HepG2) cells. The results showed that ZnO Nps could exert dose-and time-dependent cytotoxicity in HepG2 cells, and the combining treatment resulted in a greater cytotoxicity than single treatment. ZnO Nps could synergistically potentiate ISO to induce apoptosis through resulting in mitochondrial dysfunction, inhibiting the phosphorylation of Akt and ERK1/ 2, and enhancing the phosphorylation of JNK and P38. Additionally, ZnO Nps were uptaked by cells through endocytic pathway and it enhanced the cellular uptake of ISO, while no significant injury was found in normal liver cells after the combined treatment. These results suggest that the combination of metal nanoparticle with anti-cancer drugs may provide a promising alternative for novel cancer treatments. Crown Copyright (C) 2013 Published by Elsevier Ireland Ltd. All rights reserved.
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