Journal
TOXICOLOGY LETTERS
Volume 229, Issue 2, Pages 393-401Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2014.06.016
Keywords
2 ',4 '-Dihydroxy-3,4,5-trimethoxychalcone; Mitotic arrest; Anti-microtubule; Mitotic catastrophe; Apoptosis; Cancer chemotherapy
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Funding
- FCT - Fundacao para a Ciencia e a Tecnologiaunder [CEQUIMED-PEst-OE/SAU/UI4040/2014]
- CESPU [02-GCQF-CICS-2011N]
- COMPETE program [FCOMP-01-0124-FEDER-011057]
- Faculty of Science
- Department of Zoology
- graduate school scholarship of Kasetsart University, Thailand
- [4.1.3/CAPES/CPLP-GRICES 00770 29/05/08]
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We previously reported the synthesis and the anti-proliferative action of 2',4'-dihydroxy-3,4,5-trimethoxychalcone. Here we reported its mechanism of action on MCF-7 cells. The compound induced aberrant spindles, and arrested cells at metaphase/anaphase boundary with accumulation of checkpoint proteins Mad2, Bub1 and BubR1. Live cell imaging revealed that the compound sustained a prolonged mitotic arrest, followed by massive cell death. The results indicate that 2',4'-dihydroxy-3,4,5-trimethoxychalcone exerts its anti-proliferative activity by affecting microtubules and causing mitotic catastrophe, and thus has the potential for antitumor activity. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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