Journal
TOXICOLOGY LETTERS
Volume 209, Issue 1, Pages 51-57Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2011.11.024
Keywords
Gold nanorod; Silica-coated gold nanorod; Immunostimulatory; Macrophage; Cytokine
Categories
Funding
- National Research Foundation of Korea
- Ministry of Education, Science and Technology [2011-0026019]
- Converging Technology Project [KEIT 191-101-001]
- Korea Environmental Industry & Technology Institute (KEITI) [0920111900100010] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2010-0022919] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, we have investigated immunostimulatory effects of gold nanorod (Au) and silica-coated gold nanorod (SiAu) concerned with inflammatory mediators such as calcium (Ca), hydrogen peroxide, nitric oxide (NO), various cytokines, prostaglandin E2 (PGE2), transcription factors, and immune response gene in RAW 264.7 mouse macrophages. Both Au and SiAu significantly increased the release of Ca, hydrogen peroxide, NO, IL-1 alpha, IL-1 beta, IL-6, IL-10, IP-10, MCP-1, MCP-3, INF-alpha, RANTES, G-CSF, GM-CSF, LIF, MIP-2, VEGF, and PGE2 with enhancing expression of STAT1, STAT3, c-Fos, and COX-2 mRNA in RAW 264.7 cells. The results suggest that Au and SiAu have immunostimulatory properties to strengthen immune reactions via calcium-transcription factors pathway in macrophage. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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