Journal
TOXICOLOGY LETTERS
Volume 211, Issue 3, Pages 274-280Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2012.04.007
Keywords
Particulate matter; Ultrafine carbon black; Cardiac autonomic nervous system; Heart rate variability; Mice
Categories
Funding
- National Natural Science Foundation of China [81072267, 30571534]
- National High Technology Research and Development Program of China [2012AA062804]
- National Key Technologies R&D Program of China [2006BAI19B06]
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Previous epidemiological and toxicological studies have reported the associations between ambient particulate matter (PM) exposure and changes in heart rate variability (HRV), a marker of cardiac autonomic nervous system (ANS) function. However, both the responsible components in PM and their mechanisms affecting HRV remain uncertain. We propose that carbon black (CB), one of the main components in PM, may affect HRV through mechanisms independent of cardio-pulmonary and systemic inflammation and/or injury. Male C57BL/6 mice were exposed by intra-tracheal instillation to ultrafine CB (once every two days for three times) at doses of 0, 0.05, 0.15 and 0.6 mg/kg. HRV indices, standard deviation of all normal R-R intervals (SDNN) and the square root of mean of sum of squares of differences between adjacent normal R-R intervals (RMSSD), showed significant decreases in 0.15 and 0.6 mg/kg CB exposed groups. Slight pulmonary inflammation and myocardial injury were only observed in 0.6 mg/kg CB exposed group. We conclude that CB can disturb cardiac ANS function in mice, indicated by the withdrawal of parasympathetic modulation, through mechanisms independent of apparent myocardial and pulmonary injury. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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