Journal
TOXICOLOGY LETTERS
Volume 202, Issue 1, Pages 1-7Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2011.01.001
Keywords
Parkinson's disease; Tetrahydroxystilbene glucoside; Neuroprotection; PC12 cells; Apoptosis; PI3K/Akt signaling pathway
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Funding
- National Natural Sciences Foundation of China [30772742]
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Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG), which is an active component of the rhizome extract from polygonum multiflorum, shows potent antioxidant properties. In this paper, the neuroprotective effects of TSG on 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC12 cells were investigated. Pretreatment with TSG markedly attenuated MPP+-induced loss of cell viability and release of lactate dehydrogenase (LDH), and reduced MPW-induced apoptotic cell death in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated by the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway since TSG failed to rescue cells from MPP+ injury in the presence of the PI3K inhibitor, LY294002. These results indicate that TSG affords a significant neuroprotective effect against MPP+-induced damage and apoptosis in PC12 cells. The PI3K/Akt signaling pathway might be involved in the TSG-mediated anti-apoptotic effects. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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