Journal
TOXICOLOGY LETTERS
Volume 204, Issue 2-3, Pages 190-198Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2011.04.032
Keywords
Bisphenol A; Dermal exposure; Blood concentrations; Liver concentrations
Categories
Ask authors/readers for more resources
New findings on Bisphenol A (BPA) contents in thermal printing papers, and receipts, in g/kg concentrations and on its dermal uptake (up to 60%) prompted us to assess the risk arising from dermal exposure. Using physiologically based toxicokinetic modelling, we simulated concentrations in blood, in liver and kidney, the target organs exhibiting the lowest no observed adverse effect levels (NOAEL). By comparing organ concentrations at the dose level of the NOAEL divided by a safety factor of 100 (liver: 50 mu g/kg/day; kidney: 500 mu g/kg/day), with concentrations arising from the dermal dose of 0.97 mu g/kg/day (worst case assumption by Biedermann et al., 2010) this dermal exposure can be assumed safe. Additionally, based on the model simulations the high blood concentrations, reported earlier in the literature, are highly improbable because the related exposure levels are orders of magnitude higher than the currently estimated aggregate exposure levels. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available