Journal
TOXICOLOGY LETTERS
Volume 197, Issue 3, Pages 169-174Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2010.05.012
Keywords
Engineered nanoparticles; Mass; Dose; Nanotoxicology; Degradation; Safety; Core/shell; Carbon
Categories
Funding
- Swiss Federal Office of Public Health (BAG) [05.001872]
Ask authors/readers for more resources
Metal nanoparticles have distinctly different chemical and physical properties than currently investigated oxides. Since pure metallic nanoparticles are igniting at air, carbon stabilized copper nanoparticles were used as representative material for this class Using copper as a representative example, we compare the cytotoxicity of copper metal nanoparticles stabilized by a carbon layer to copper oxide nanoparticles using two different cell lines Keeping the copper exposure dose constant, the two forms of copper showed a distinctly different response Whilst copper oxide had already been reported to be highly cytotoxic, carbon-coated copper nanoparticles were much less cytotoxic and more tolerated. Measuring the two material's intra- and extracellular solubility in model buffers explained this difference on the basis of altered copper release when supplying copper metal or the corresponding oxide particles to the cells Control experiments using pure carbon nanoparticles were used to exclude significant surface effects. Reference experiments with ionic copper solutions confirmed a similar response of cultures if exposed to copper oxide nanoparticles or ionic copper. These observations are in line with a Trojan horse-type mechanism and illustrate the dominating influence of physico-chemical parameters on the cytotoxicity of a given metal. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available