Journal
TOXICOLOGY LETTERS
Volume 198, Issue 2, Pages 93-99Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2010.06.022
Keywords
Neurotoxicity; Toluene; Neuroimmune factors; Mice; Hippocampus
Categories
Funding
- Ministry of the Environment
- Ministry of Education, Culture, Sports, Science and Technology [21390198]
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Chemical susceptibility is triggered by a large range of chemicals present both indoors and outdoors including pesticides, cleaning products, perfumes, scented products and cigarette smoke. Health risk after chemical exposure depends on age, sex, genetic factors, socioeconomic status, nutritional status, and environmental factors. Toluene is one of volatile organic chemicals that causes different sensitivity in individuals. Although neurotoxic and immunotoxic effects of toluene have been studied extensively, the underlying mechanism remains obscure. This review highlights the possible neuroimmune factors influencing toluene sensitivity and neurotoxicity in a mouse model. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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