Journal
TOXICOLOGY LETTERS
Volume 198, Issue 3, Pages 324-330Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2010.07.009
Keywords
Silicon carbide; Nanoparticles; Characterization; Toxicity; Oxidative stress
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Funding
- French national research agency (ANR)
- French agency for sanitary safety of the environment (AFSSET)
- Ile-de-France region in the framework of C'nano IdF
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Silicon carbide (SiC) is considered a highly biocompatible material, consequently SIC nanoparticles (NPs) have been proposed for potential applications in diverse areas of technology. Since no toxicological data are available for these NPs, the aim of this study was to draw their global toxicological profile on A549 lung epithelial cells, using a battery of classical in vitro assays. Five SiC-NPs, with varying diameters and Si/C ratios were used, and we show that these SiC-NPs are internalized in cells where they cause a significant, though limited, cytotoxic effect. Cell redox status is deeply disturbed: SiC-NP exposure cause reactive oxygen species production, glutathione depletion and inactivation of some antioxidant enzymes: glutathione reductase, superoxide dismutase, but not catalase. Finally, the alkaline comet assay shows that SiC-NPs are genotoxic. Taken together, these data prove that SiC-NPs biocompatibility should be revisited. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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