Journal
TOXICOLOGY LETTERS
Volume 188, Issue 1, Pages 33-37Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2009.03.002
Keywords
Di-n-butyl phthalate; Diisobutyl phthalate; Exposure; Urine; Biomonitoring; Risk assessment
Categories
Ask authors/readers for more resources
Phthalates like di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) are commonly used as plasticisers, enteric coatings in medications and their metabolites (MnBP respectively MiBP) are suspect of adverse endocrine activities. The aim of this study was to determine kinetical data in humans after the application of a drug containing 3600 mu g of DnBP and to quantify main metabolites of DnBP and DiBP with and without glucuronidase treatment. Since commonly glucuronides do not exhibit endocrine activity it is of interest to determine the potentially active metabolite like free MnBP and MiBP for a valid risk assessment. After the application of one capsule containing 3600 mu g of DnBP to 17 volunteers 78% (median of 2248 mu g of total MnBP) of administered DnBP was found within 24 h in urine. After 24 h the levels of MnBP in urine were comparable to concentrations before administration showing a fast elimination. In contrast to controls in all urine samples collected within 24 h after the administration of the drug free MnBP was observed with a median of 4% of total MnBP. In controls total MnBP and MiBP were found in median concentration of 23 mu g/24 h and about 50 mu g/24 h, respectively and therefore environmental exposure to DnBP is only 1% compared to medication. Since an uptake of 3600 mu g in only one capsule is already above the tolerable daily intake (TDI) for DnBP of 10 mu g/kg b.w. from a preventive health protection DnBP should be replaced in medical drugs. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available