Journal
TOXICOLOGY LETTERS
Volume 188, Issue 1, Pages 45-51Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2009.03.006
Keywords
Cadmium; Apoptosis; Apoptosis-inducing factor; Ascorbic acid; Testes
Categories
Funding
- Korea Research Foundation
- Korean Government (MOEHRD) [KRF-2006005-J03002]
- Chonnam National Univ.
- National Research Foundation of Korea [과06B1213, 2006-005-J03002] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Cadmium (Cd) is a highly toxic metal that affects a variety of cellular events, such as cell proliferation, differentiation and survival. Cd generates reactive oxygen species (ROS) that induce apoptosis. We previously demonstrated that Cd induces apoptosis in testicular germ cells and that apoptosis was prevented by the administration of ascorbic acid (AA), an ROS scavenger. However, little is known about the signaling pathways underlying Cd-induced apoptosis in rat testes. Here, we report that Cd-induced apoptosis in rat testes was associated with the translocation of apoptosis inducing factor (AIF) from mitochondria to the nucleus, and that this was prevented by treatment with AA. Cd-induced cleavage of poly ADP-ribose polymerase-1 (PARP-1), and this was also inhibited by treatment with AA. Taken together, these results suggest that Cd-induced ROS was responsible for the upregulation of PARP-1, the translocation of AIF to the nucleus, and apoptosis of testicular cells in rat testes. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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