Journal
TOXICOLOGY LETTERS
Volume 184, Issue 2, Pages 81-84Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2008.10.017
Keywords
Ciprofloxacin; Levofloxacin; Fluoroquinolone; Dysglycemia; Glucose transport; GLUT1
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Dysglycemia and central nervous system (CNS) complications are the known adverse effects of fluoroquinolone antibiotics. Ciprofloxacin and levofloxacin are among the most prescribed antibiotics. In this Study we demonstrate that ciprofloxacin and levofloxacin disturb glucose transport into HepG2 cells and such inhibition is associated with inhibited glucose transporter type 1 (GLUT1) function. When exposed to ciprofloxacin or levofloxacin at maximum plasma concentrations (C-max) and 5x of C-max concentrations, GLUT1 mRNA expression, cell surface GLUT1 protein expression and glucose uptake were significantly reduced. These findings imply that disturbed cellular glucose transport and GLUT1 function may underlie the dysglycemic and CNS effects of ciprofloxacin and levofloxacin. (C) 2008 Elsevier Ireland Ltd. All rights reserved
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