Journal
TOXICOLOGY IN VITRO
Volume 27, Issue 4, Pages 1260-1266Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2013.02.017
Keywords
Mytilus galloprovincialis; Cell volume regulation; Digestive cells; Heavy metal; Pollution effect; Sublethal effect
Categories
Ask authors/readers for more resources
This study investigated the role of cadmium, a widespread heavy metal in the aquatic environment, on cell volume regulation of digestive cells isolated from the digestive gland of Mytilus galloprovincialis. These cells when exposed to a rapid change (from 1100 to 800 mOsm/kg) of the bathing solution osmolality swelled but thereafter underwent a Regulatory Volume Decrease (RVD), tending to recover the original size. This homeostatic response is altered by cadmium, as suggested by experiments performed both on isolated cells pre-incubated with cadmium (10(-5) M) and on cells isolated from animals exposed to sub-lethal concentrations of the metal (40 mu g/l for 21 days). It is suggested that cytoskeleton and Na+/K(+)ATPase are the possible targets of cadmium which impairment is responsible of the altered homeostatic response. (C) 2013 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available