Journal
TOXICOLOGY IN VITRO
Volume 26, Issue 5, Pages 727-731Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2012.03.013
Keywords
Transactivation assays; Bisphenol A plus S; Estrogenic activity; Babybottles; Validation; Performance-based test guideline
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In 2011, the European Commission has restricted the use of Bisphenol A in plastic infant feeding bottles. In a response to this restriction, Bisphenol S is now often used as a component of plastic substitutes for the production of babybottles. One of the major concerns leading to the restriction of Bisphenol A was its weak estrogenic activity. By using two highly standardised transactivation assays, we could demonstrate that the estrogenic activity of Bisphenol A and Bisphenol S is of a comparable potency. Furthermore, some insights about the structure-activity relationships of these two chemicals and their metabolites could be gained from in silico predictions of their relative estrogen receptor-binding affinities and their liver phase-I biotransformation. (C) 2012 Elsevier Ltd. All rights reserved.
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