Journal
TOXICOLOGY IN VITRO
Volume 25, Issue 8, Pages 1764-1770Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2011.09.005
Keywords
Yessotoxin; Paraptosis; Cytoplasmic vacuolation; Apoptosis; Mitochondria; Endoplasmic reticulum; MAP kinase; DNA fragmentation
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Funding
- Norwegian School of Veterinary Science, Department of Food Safety and Infection Biology
- Astri and Birger Torsteds Legacy
- Olav Raagholt og Gerd Meidel Raagholts legacy
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This study shows that BC3H1 myoblast cell lines exposed to 100 nM yessotoxin (YTX) undergo a form of programmed cell death distinct from apoptosis and with features resembling paraptosis. Morphologically, cells treated with YTX reveal extensive cytoplasmic vacuolation, mitochondrial and endoplasmic reticulum swelling, uncondensed chromatin and cytoskeletal alterations. DNA electrophoresis evidences lack of DNA fragmentation and Western blotting analysis demonstrates activation of the mitogen-activated protein kinase JNK/SAPK1. Further characterisation of this form of programmed cell death may have interest within medicine and cancer therapy. (C) 2011 Elsevier Ltd. All rights reserved.
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