Journal
TOXICOLOGY IN VITRO
Volume 22, Issue 2, Pages 457-467Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2007.09.010
Keywords
tissue : plasma partition coefficients; tissue distribution; tissue exposure; PBPK modeling
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A new mechanistic, universal model for the calculation of steady state tissue:plasma partition coefficients (K-t:p) of organic chemicals in mammalian species was developed. The approach allows the estimation of K-t:p-values based on the composition of the tissues in terms of water, neutral lipids, neutral and acidic phospholipids and proteins using the lipophilicity, the binding to phospholipid membranes, the pK(a) and the unbound fraction in blood plasma as compound specific parameters. Taking explicitly into account the sign and fraction of the charge of the compounds at the physiological pH the method is universally applicable to neutral, acidic, basic or multiply charged substances and has thus a significantly extended applicability compared to previously published approaches. The model was applied to 59 chemically diverse drug compounds for which tissue:plasma partition coefficients are reported in the literature. In total 474 experimentally observed K-t:p values for 12 tissues and the red blood cells were available and could be compared to model results. For 73% of the calculated values a deviation less than 3-fold from the respective observed value was found, proving the validity of the approach. (C) 2007 Elsevier Ltd. All rights reserved.
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