Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume 275, Issue 2, Pages 145-151Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2013.12.022
Keywords
Autophagy; Oxidative stress; Pulmonary toxicants; Cytotoxicity; Lung injury; p62
Categories
Funding
- NIH [U54AR055073, K08HL096426, R01ES004738, R01CA132624, P30ES005022]
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Autophagy is an evolutionarily conserved catabolic process important in regulating the turnover of essential proteins and in elimination of damaged organelles and protein aggregates. Autophagy is observed in the lung in response to oxidative stress generated as a consequence of exposure to environmental toxicants. Whether autophagy plays role in promoting cell survival or cytotoxicity is unclear. In this article recent findings on oxidative stress-induced autophagy in the lung are reviewed; potential mechanisms initiating autophagy are also discussed. A better understanding of autophagy and its role in pulmonary toxicity may lead to the development of new strategies to treat lung injury associated with oxidative stress. (C) 2013 Published by Elsevier Inc.
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