Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume 259, Issue 3, Pages 311-319Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2012.01.007
Keywords
Lipid raft; Cholesterol; Death receptor; Kinase; Calcium channel; Apoptosis
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Funding
- NIH [RO1CA086928]
- Ohio University
- College of Arts and Science at Ohio University
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Lipid rafts are microdomains of the plasma membrane enriched in cholesterol and sphingolipids, and play an important role in the initiation of many pharmacological agent-induced signaling pathways and toxicological effects. The structure of lipid rafts is dynamic, resulting in an ever-changing content of both lipids and proteins. Cholesterol, as a major component of lipid rafts, is critical for the formation and configuration of lipid raft microdomains, which provide signaling platforms capable of activating both pro-apoptotic and antiapoptotic signaling pathways. A change of cholesterol level can result in lipid raft disruption and activate or deactivate raft-associated proteins, such as death receptor proteins, protein kinases, and calcium channels. Several anti-cancer drugs are able to suppress growth and induce apoptosis of tumor cells through alteration of lipid raft contents via disrupting lipid raft integrity. Published by Elsevier Inc.
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