Journal
TOXICOLOGY AND APPLIED PHARMACOLOGY
Volume 244, Issue 1, Pages 16-20Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.taap.2009.07.034
Keywords
Oxidative stress; bZIP factor; Nrf1; Nrf2; Antioxidant
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Funding
- NCI NIH HHS [R01 CA091907, R01 CA091907-05] Funding Source: Medline
- NIDDK NIH HHS [K08 DK002603-01, R03 DK063757-01] Funding Source: Medline
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Oxidative stress plays an important part in the pathogenesis of a variety of diseases. The ability to mount an efficient response against the continuous threat posed by exogenous and endogenous oxidants is essential for cellular homeostasis and survival. Oxidative stress activates transcription of a variety of antioxidant genes through cis-acting sequence known as antioxidant response element (ARE). Members of the Cap-N-Collar family of transcription factors, including Nrf1 and Nrf2, that bind ARE have been identified. Nrf1 and Nrf2 are expressed in a wide range of tissues and cell types, and both bind the ARE as heterodimers with small Maf proteins. Numerous studies indicate a pivotal role of Nrf2 in ARE function. Herein, we review data derived from cell-based studies and knockout mice in an attempt to define the role and regulation of Nrf1 in oxidative stress response and other functions. (C) 2009 Elsevier Inc. All rights reserved.
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