Journal
TOXICOLOGY
Volume 308, Issue -, Pages 122-128Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2013.03.010
Keywords
Polybrominated diphenyl ethers (PBDEs); 2,2 ',4,4 ',5-pentaBDE (BDE-99); Brain derived neurotrophic factor (BDNF); Thyroid receptors (TRs); Thyroid hormones (THs)
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Funding
- Fondo de Investigacion Sanitaria
- Ministry of Health, Spain [P107631]
- FEDER funds
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Exposure of pregnant women to polybrominated diphenyl ethers (PBDEs) may mean serious health risks. The main goal of the present study was to examine the neurobehavioral changes in rat offspring that were perinatally exposed to one of the most prevalent PBDEs congeners found in humans, 2,2',4,4',5-pentaBDE (BDE-99). Rat dams were exposed to 0,1 and 2 mg/kg/day of BDE-99 from gestation day 6 to post-natal day 21. When pups were weaning, cortex and hippocampal gene expressions of brain-derived neurotrophic factor (BDNF) of the different isoforms of the thyroid hormone (TH) receptors (TRs) were evaluated. Serum TH levels were also determined. The remaining pups were assessed by neurobehavioral testing for learning and memory function. The results showed that maternal transference of BDE-99 produced a delay in the spatial learning task in the water maze test. Moreover, the open-field test revealed a significant dose-response anxiolytic effect. It was also found that the serum levels of triiodothyronine (T3), tetraiiodothyronine (T4) and free-T4 (FT4) decreased. Although no effect on the gene expression of the different isoforms of TRs was observed, the expression of the TH-mediated gene BDNF was downregulated in the hippocampus. These results indicate a clear signal disruption of TH and reinforce previous studies in which neurotoxic effects of PBDEs in animal research were observed at levels comparable to those found in humans. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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