Journal
TOXICOLOGY
Volume 313, Issue 1, Pages 49-58Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.tox.2012.11.011
Keywords
Multiwall carbon nanotubes; PC12 cells; Metal impurities; Neuron; Differentiation; Neurotoxicity
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Funding
- Ministry of Science and Technology of China [2011CB933401, 2012CB934003]
- National Natural Science Foundation of China [10975040]
- National Major Scientific Instruments Development Project [2011YQ03013406]
- Danish Agency for Science Technology and Innovation [09-067185]
- European Commission through the Seventh Framework Programme for Research and Technological Development [263215]
- [NIHR15 ES021079-01]
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The increasing use of carbon nanotubes (CNTs) in biomedical applications has garnered a great concern on their potential negative effects to human health. CNTs have been reported to potentially disrupt normal neuronal function and they were speculated to accumulate and cause brain damage, although a lot of distinct and exceptional properties and potential wide applications have been associated with this material in neurobiology. Fe impurities strapped inside the CNTs may be partially responsible for neurotoxicity generation. In the present study, we selected rat pheochromocytoma (PC12) cells to investigate and compare the effects of two kinds of multiwall carbon nanotubes (MWCNTs) with different concentrations of Fe impurities which usually come from the massive production of CNTs by chemical vapor deposition. Exposure to Fe-high MWCNTs can reduce cell viability and increase cytoskeletal disruption of undifferentiated PC12 cells, diminish the ability to form mature neurites, and then adversely influence the neuronal dopaminergic phenotype in NGF-treated PC-12 cells. The present results highlight the critical role of iron residue in the adverse response to MWCNTs exposure in neural cells. These findings provide useful information for understanding the toxicity and safe application of carbon nanotubes. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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